Acetylcholine activity in selective striatal regions supports behavioral flexibility
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چکیده
منابع مشابه
Acetylcholine activity in selective striatal regions supports behavioral flexibility.
Daily living often requires individuals to flexibly respond to new circumstances. There is considerable evidence that the striatum is part of a larger neural network that supports flexible adaptations. Cholinergic interneurons are situated to strongly influence striatal output patterns which may enable flexible adaptations. The present experiments investigated whether acetylcholine actions in d...
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Acetylcholine is one of the major neurotransmitters in the brain. The highest density of cholinergic markers is found in the striatum, a basal ganglia region that has been associated with behavioral flexibility. In our recent study, we showed a causal role of the cholinergic interneurons of the striatum in set-shifting in the rat. The set-shifting task required an attentional shift from one sti...
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Recent evidence suggests that a circuit involving the centromedian-parafascicular (Pf) thalamus and basal ganglia is critical for a shift away from biased actions. In particular, excitatory input from the Pf onto striatal cholinergic neurons may facilitate behavioral flexibility. Accumulating evidence indicates that an endogenous increase in dorsomedial striatal acetylcholine (ACh) output enhan...
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ژورنال
عنوان ژورنال: Neurobiology of Learning and Memory
سال: 2009
ISSN: 1074-7427
DOI: 10.1016/j.nlm.2008.09.008